Associate Professor of Chemistry

Office: Johnson EPS 301D

Phone: 731-881-7460

Email: gsmith65@utm.edu

 

Education:

B.S. Chemistry – Fort Lewis College, Durango, CO

Ph.D. Organic Chemistry – Colorado State University, Fort Collins, CO

 

Industrial Experience:

Absolute Science, Lexington, MA

Cetek Corporation, Marlborough, MA

Momenta Pharmaceuticals, Cambridge, MA

 

Courses Taught:

CHEM 112 – Introduction to Organic and Biochemistry

CHEM 121-122 – General Chemistry

CHEM 341-342 – Organic Chemistry

CHEM 350 – Medicinal Chemistry

GENS 101 ­– Freshman Studies

 

Research:

 

Lauroside B (1) is a naturally occurring molecule that was first extracted from Sweet Bay Laurel in 2004.  In 2011, researchers demonstrated that 1 has potent biological activity against malignant skin cancer cells, making it an attractive target for laboratory synthesis.  Research in the Smith Group is focused on a synthetic route to access 1 via the intermediate synthesis of Vomifoliol (2).

 

Publications:

Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.  Jacobson, A.R., Adler, M., Silvaggi, N.R., Allen, K.N., Smith, G.M., Fredenburg, R.A., Stein, R.L., Park, J.-B., Feng, X., Shoemaker, C.B., Deshpande, S.S., Goodnough, M.C., Malizio, C.J., Johnson, E.A., Pellett, S., Tepp, W.H., Tzipori, S.  Toxicon, 2017, 137, pp. 36-47.

 

Synthetic studies toward citrinadin A: Construction of the pentacyclic core.  

McCallum, M.E., Smith, G.M., Matsumaru, T., Kong, K., Enquist, J.A., Wood, J.L.

Journal of Antibiotics, 2016, 69 (4), pp. 331-336.

 

Synthetic studies toward the citrinadins: Enantioselective preparation of an advanced spirooxindole intermediate.  Matsumaru, T., McCallum, M.E., Enquist Jr., J.A., Smith, G.M., Kong, K., Wood, J.L. Tetrahedron, 2014, 70 (27-28), pp. 4089-4093.

 

An Enantioselective Total Synthesis and Stereochemical Revision of (+)-Citrinadin B. Kong, K; Enquist, J.; McCallum, M.; Smith, G.; Matsumaru, T.; Menhaji-Klotz, E.; Wood, J.  J. Am. Chem. Soc., 2013, 135 (30), pp. 10890–10893.

 

Botulinum neurotoxin serotype A inhibitors: Small-molecule mercaptoacetamide analogs.  Moe, S.T., Thompson, A.B., Smith, G.M., Fredenburg, R.A., Stein, R.L., Jacobson, A.R. Bioorganic and Medicinal Chemistry, 2009, 17 (8), pp. 3072-3079.

 

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